FAM3B

Protein-coding gene in the species Homo sapiens
FAM3B
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2YOP, 2YOQ

Identifiers
AliasesFAM3B, 2-21, C21orf11, C21orf76, ORF9, PANDER, PRED44, family with sequence similarity 3 member B, FAM3 metabolism regulating signaling molecule B
External IDsOMIM: 608617; MGI: 1270150; HomoloGene: 10766; GeneCards: FAM3B; OMA:FAM3B - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for FAM3B
Genomic location for FAM3B
Band21q22.3Start41,304,212 bp[1]
End41,357,727 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for FAM3B
Genomic location for FAM3B
Band16 C4|16 57.47 cMStart97,272,165 bp[2]
End97,316,016 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • parotid gland

  • jejunal mucosa

  • duodenum

  • body of pancreas

  • pancreatic epithelial cell

  • pancreatic ductal cell

  • oral cavity

  • olfactory zone of nasal mucosa

  • corpus epididymis
Top expressed in
  • gastric mucosa

  • epithelium of stomach

  • pyloric antrum

  • mucous cell of stomach

  • seminal vesicula

  • duodenum

  • jejunum

  • left colon

  • intestinal villus

  • seminiferous tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cytokine activity
Cellular component
  • extracellular region
  • extracellular exosome
  • extracellular space
Biological process
  • insulin secretion
  • apoptotic process
  • regulation of signaling receptor activity
  • glucose homeostasis
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54097

52793

Ensembl

ENSG00000183844

ENSMUSG00000022938

UniProt

P58499

Q9D309

RefSeq (mRNA)

NM_058186
NM_206964

NM_020622

RefSeq (protein)

NP_478066
NP_996847

NP_065647

Location (UCSC)Chr 21: 41.3 – 41.36 MbChr 16: 97.27 – 97.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein FAM3B is a protein that in humans is encoded by the FAM3B gene.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183844 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022938 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: FAM3B family with sequence similarity 3, member B".

Further reading

  • Yang J, Robert CE, Burkhardt BR, Young RA, Wu J, Gao Z, Wolf BA (November 2005). "Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells". Diabetes. 54 (11): 3217–28. doi:10.2337/diabetes.54.11.3217. PMID 16249448.
  • Yang J, Gao Z, Robert CE, Burkhardt BR, Gaweska H, Wagner A, Wu J, Greene SR, Young RA, Wolf BA (August 2005). "Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells". Biochemistry. 44 (34): 11342–52. doi:10.1021/bi0503908. PMID 16114871.
  • Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR (August 2002). "Cloning, expression, and initial characterization of a novel cytokine-like gene family". Genomics. 80 (2): 144–50. doi:10.1006/geno.2002.6816. PMID 12160727.
  • Reymond A, Friedli M, Henrichsen CN, Chapot F, Deutsch S, Ucla C, Rossier C, Lyle R, Guipponi M, Antonarakis SE (November 2001). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics. 78 (1–2): 46–54. doi:10.1006/geno.2001.6640. PMID 11707072.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Protein FAM3B


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