GTF3C4

Protein-coding gene in the species Homo sapiens
GTF3C4
Identifiers
AliasesGTF3C4, KAT12, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA, TF3C-delta, general transcription factor IIIC subunit 4
External IDsOMIM: 604892; MGI: 2138937; HomoloGene: 8147; GeneCards: GTF3C4; OMA:GTF3C4 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for GTF3C4
Genomic location for GTF3C4
Band9q34.13Start132,670,035 bp[1]
End132,694,953 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for GTF3C4
Genomic location for GTF3C4
Band2|2 A3Start28,822,299 bp[2]
End28,840,360 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • ventricular zone

  • gingival epithelium

  • islet of Langerhans

  • ganglionic eminence

  • testicle

  • hair follicle

  • stromal cell of endometrium

  • middle temporal gyrus

  • skin of thigh
Top expressed in
  • ureter

  • medullary collecting duct

  • saccule

  • otic placode

  • vas deferens

  • renal corpuscle

  • otic vesicle

  • fossa

  • condyle

  • vestibular sensory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • histone acetyltransferase activity
  • transferase activity
  • DNA binding
  • enzyme activator activity
  • acyltransferase activity
  • protein binding
Cellular component
  • transcription factor TFIIIC complex
  • nucleoplasm
  • nucleus
  • mitochondrion
Biological process
  • tRNA transcription by RNA polymerase III
  • 5S class rRNA transcription by RNA polymerase III
  • transcription initiation from RNA polymerase III promoter
  • transcription, DNA-templated
  • positive regulation of catalytic activity
  • transcription by RNA polymerase III
  • histone acetylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9329

269252

Ensembl

ENSG00000125484

ENSMUSG00000035666

UniProt

Q9UKN8

Q8BMQ2

RefSeq (mRNA)

NM_012204

NM_001166033
NM_172977

RefSeq (protein)

NP_036336

NP_001159505
NP_766565

Location (UCSC)Chr 9: 132.67 – 132.69 MbChr 2: 28.82 – 28.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

General transcription factor 3C polypeptide 4 is a protein that in humans is encoded by the GTF3C4 gene.[5][6]

Interactions

GTF3C4 has been shown to interact with GTF3C2,[5] GTF3C1,[5] POLR3C[5][7] and GTF3C5.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125484 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035666 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c d e Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  6. ^ "Entrez Gene: GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa".
  7. ^ Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.

Further reading

  • Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.


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