KCTD13

Protein-coding gene in the species Homo sapiens
KCTD13
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UIJ

Identifiers
AliasesKCTD13, BACURD1, PDIP1, POLDIP1, hBACURD1, FKSG86, potassium channel tetramerization domain containing 13
External IDsOMIM: 608947; MGI: 1923739; HomoloGene: 27800; GeneCards: KCTD13; OMA:KCTD13 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for KCTD13
Genomic location for KCTD13
Band16p11.2Start29,905,012 bp[1]
End29,926,236 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for KCTD13
Genomic location for KCTD13
Band7|7 F3Start126,528,051 bp[2]
End126,544,803 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • nucleus accumbens

  • anterior cingulate cortex

  • right frontal lobe

  • prefrontal cortex

  • amygdala

  • Region I of hippocampus proper

  • caudate nucleus

  • right hemisphere of cerebellum
Top expressed in
  • primary visual cortex

  • superior frontal gyrus

  • subiculum

  • zygote

  • dentate gyrus

  • dentate gyrus of hippocampal formation granule cell

  • piriform cortex

  • globus pallidus

  • cingulate gyrus

  • hippocampus proper
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • ubiquitin-protein transferase activity
  • protein binding
  • identical protein binding
  • protein domain specific binding
Cellular component
  • Cul3-RING ubiquitin ligase complex
  • nucleus
  • nuclear body
Biological process
  • positive regulation of DNA replication
  • DNA replication
  • protein homooligomerization
  • cell migration
  • protein ubiquitination
  • stress fiber assembly
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • negative regulation of Rho protein signal transduction
  • positive regulation of synaptic transmission
  • neural precursor cell proliferation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

253980

233877

Ensembl

ENSG00000174943

ENSMUSG00000030685

UniProt

Q8WZ19

Q8BGV7

RefSeq (mRNA)

NM_178863

NM_172747

RefSeq (protein)

NP_849194

NP_766335

Location (UCSC)Chr 16: 29.91 – 29.93 MbChr 7: 126.53 – 126.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BTB/POZ domain-containing protein KCTD13 is a protein that in humans is encoded by the KCTD13 gene.[5][6]

Interactions

KCTD13 has been shown to interact with PCNA.[5]

Clinical relevance

Mutations in this gene have been associated to abnormalities in brain growth and behaviour.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174943 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030685 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b He H, Tan CK, Downey KM, So AG (October 2001). "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 98 (21): 11979–84. Bibcode:2001PNAS...9811979H. doi:10.1073/pnas.221452098. PMC 59753. PMID 11593007.
  6. ^ "Entrez Gene: KCTD13 potassium channel tetramerisation domain containing 13".
  7. ^ Arbogast T, Razaz P, Ellegood J, McKinstry SU, Erdin S, Currall B, et al. (May 2019). "Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions". Human Molecular Genetics. 28 (9): 1474–1486. doi:10.1093/hmg/ddy436. PMC 6489413. PMID 30590535.

Further reading

  • Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, et al. (July 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
  • Zhou J, Hu X, Xiong X, Liu X, Liu Y, Ren K, et al. (March 2005). "Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen". Journal of Experimental Zoology A. 303 (3): 227–40. Bibcode:2005JEZA..303..227Z. doi:10.1002/jez.a.150. PMID 15726626.
  • Tomaru T, Satoh T, Yoshino S, Ishizuka T, Hashimoto K, Monden T, et al. (January 2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology. 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human KCTD13


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