PPM1G

Protein-coding gene in the species Homo sapiens
PPM1G
Identifiers
AliasesPPM1G, PP2CG, PP2CGAMMA, PPP2CG, protein phosphatase, Mg2+/Mn2+ dependent 1G
External IDsOMIM: 605119; MGI: 106065; HomoloGene: 31106; GeneCards: PPM1G; OMA:PPM1G - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PPM1G
Genomic location for PPM1G
Band2p23.3Start27,381,195 bp[1]
End27,409,591 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for PPM1G
Genomic location for PPM1G
Band5 B1|5 17.27 cMStart31,360,008 bp[2]
End31,378,031 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • ganglionic eminence

  • sperm

  • ventricular zone

  • islet of Langerhans

  • mucosa of transverse colon

  • gastrocnemius muscle

  • granulocyte

  • stromal cell of endometrium
Top expressed in
  • fetal liver hematopoietic progenitor cell

  • spermatid

  • ectoderm

  • otic vesicle

  • otic placode

  • epiblast

  • seminiferous tubule

  • spermatocyte

  • tibiofemoral joint

  • primitive streak
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein serine/threonine phosphatase activity
  • protein binding
  • catalytic activity
  • phosphoprotein phosphatase activity
  • hydrolase activity
  • metal ion binding
  • cation binding
Cellular component
  • cytoplasm
  • membrane
  • nucleus
  • nucleoplasm
Biological process
  • protein dephosphorylation
  • peptidyl-threonine dephosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5496

14208

Ensembl

ENSG00000115241

ENSMUSG00000029147

UniProt

O15355
Q6IAU5

Q61074

RefSeq (mRNA)

NM_177983

NM_008014

RefSeq (protein)

NP_817092
NP_817092.1

NP_032040

Location (UCSC)Chr 2: 27.38 – 27.41 MbChr 5: 31.36 – 31.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase 1G is an enzyme that in humans is encoded by the PPM1G gene.[5][6]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115241 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029147 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Travis SM, Welsh MJ (Sep 1997). "PP2C gamma: a human protein phosphatase with a unique acidic domain". FEBS Lett. 412 (3): 415–9. doi:10.1016/S0014-5793(97)00837-5. PMID 9276438. S2CID 82436336.
  6. ^ a b "Entrez Gene: PPM1G protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform".

Further reading

  • Guthridge MA, Bellosta P, Tavoloni N, Basilico C (1997). "FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression". Mol. Cell. Biol. 17 (9): 5485–98. doi:10.1128/mcb.17.9.5485. PMC 232397. PMID 9271424.
  • Murray MV, Kobayashi R, Krainer AR (1999). "The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor". Genes Dev. 13 (1): 87–97. doi:10.1101/gad.13.1.87. PMC 316367. PMID 9887102.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Flajolet M, Rakhilin S, Wang H, et al. (2004). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16006–11. doi:10.1073/pnas.2136600100. PMC 307683. PMID 14663150.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Maynes JT, Luu HA, Cherney MM, et al. (2006). "Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins". J. Mol. Biol. 356 (1): 111–20. doi:10.1016/j.jmb.2005.11.019. PMID 16343532.
  • Suh EJ, Kim TY, Kim SH (2007). "PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1)". FEBS Lett. 580 (26): 6100–4. doi:10.1016/j.febslet.2006.10.005. PMID 17054950. S2CID 81205783.
  • Kimura H, Takizawa N, Allemand E, et al. (2006). "A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B". J. Cell Biol. 175 (3): 389–400. doi:10.1083/jcb.200608001. PMC 2064517. PMID 17074886.
  • Luo W, Peterson A, Garcia BA, et al. (2007). "Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex". EMBO J. 26 (6): 1511–21. doi:10.1038/sj.emboj.7601607. PMC 1829374. PMID 17318175.
  • Allemand E, Hastings ML, Murray MV, et al. (2007). "Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1". Nat. Struct. Mol. Biol. 14 (7): 630–8. doi:10.1038/nsmb1257. PMID 17572683. S2CID 3187530.
  • Petri S, Grimmler M, Over S, et al. (2007). "Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex". J. Cell Biol. 179 (3): 451–65. doi:10.1083/jcb.200704163. PMC 2064792. PMID 17984321.


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