Temocapril
Chemical compound
- C09AA14 (WHO)
- 2-[(2S)-6-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
- 111902-57-9
- 71323
- 64431
- 18IZ008EU6
- D08566 Y
- ChEMBL2110627
- DTXSID3048239
- Interactive image
- CCOC(=O)[C@H](CCc1ccccc1)NC2CS[C@@H](CN(C2=O)CC(=O)O)c3cccs3
InChI
- InChI=1S/C23H28N2O5S2/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)/t17-,18?,20-/m0/s1
- Key:FIQOFIRCTOWDOW-DXCJPMOASA-N
Temocapril (also known as temocaprilum [Latin]; brand name Acecol) is an ACE inhibitor. It was not approved for use in the US.
It is administered as inactive prodrug, then converted to its active metabolite, temocaprilat.[1]
It was patented in 1984 and approved for medical use in 1994.[2]
References
- ^ Yasunari, K., Maeda, K., Nakamura, M., Watanabe, T., Yoshikawa, J., & Asada, A. (2004). Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile. Cardiovascular drug reviews, 22(3), 189–198. https://doi.org/10.1111/j.1527-3466.2004.tb00140.x
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 469. ISBN 9783527607495.
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Antihypertensive drugs acting on the renin–angiotensin system (C09)
("-pril")
- Sulfhydryl-containing: Captopril
- Rentiapril
- Zofenopril
- Dicarboxylate-containing: Enalapril#
- Benazepril
- Cilazapril
- Delapril
- Imidapril
- Lisinopril (+amlodipine, +HCT)
- Moexipril
- Perindopril (+indapamide)
- Quinapril (+HCT)
- Ramipril
- Spirapril
- Temocapril
- Trandolapril
- Phosphonate-containing: Ceronapril
- Fosinopril (+HCT)
- Other/ungrouped: Alacepril
("-sartan")
("-kiren")
- Gemopatrilat
- Ilepatril
- Omapatrilat
- Sampatrilat
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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