CHST4

Identifikatori

Alijasi

CHST4

Spoljašnji ID

MGI: 1349479 HomoloGene: 4216 GeneCards: CHST4

Genska lokacija (miš)

Hr.	Chromosome 8 (mouse)^[1]

Band	8\|8 D3	Start	110,755,785 bp^[1]
Band	8\|8 D3	Kraj	110,766,372 bp^[1]

Obrazac RNK izražavanja

More reference expression data

Genska ontologija
Molecular function	• transferase activity • sulfotransferase activity • N-acetylglucosamine 6-O-sulfotransferase activity
Cellular component	• саставни део мембране • Голџијев апарат • intrinsic component of Golgi membrane • мембрана • Golgi membrane • trans-Golgi network
Biological process	• cell-cell signaling • Ćelijska adhezija • GO:0046730, GO:0046737, GO:0046738, GO:0046736 имуни одговор • O-glycan processing • sulfur compound metabolic process • protein sulfation • запаљенска реакција • N-acetylglucosamine metabolic process • keratan sulfate biosynthetic process • Метаболизам угљених хидрата
Sources:Amigo / QuickGO

Ortolozi

Vrste

Čovek

Miš

Entrez


10164


26887

Ensembl


ENSG00000140835


ENSMUSG00000035930

UniProt


Q8NCG5


Q9R1I1

RefSeq (mRNA)


NM_005769 NM_001166395


NM_011998

RefSeq (protein)


NP_001159867 NP_005760


NP_036128

Location (UCSC)

n/a

Chr 8: 110.76 – 110.77 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Ugljeno hidratna sulfotransferaza 4 (eng. Carbohydrate sulfotransferase 4) je enzim koji je kod ljudi kodiran istoimenim genom CHST4^[4]^[5], nalazi se na kratkom kraku 16 hromozoma.^[6] Dužina polipeptidnog lanca je 386 aminokiselina, a molekulska težina 45.134.^[7]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000035930 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S (јул 1999). „Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin”. J Cell Biol. 145 (4): 899—910. PMC 2133194 . PMID 10330415. doi:10.1083/jcb.145.4.899. CS1 одржавање: Формат датума (веза)
^ „Entrez Gene: CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4”.
^ „HUGO Gene Nomenclature Commitee, HGNC:1972” (на језику: eng.). Приступљено 11. 09. 2017. CS1 одржавање: Непрепознат језик (веза)
^ „UniProt, Q8NCG5” (на језику: eng .). Архивирано из оригинала 24. 09. 2016. г. Приступљено 07. 06. 2024. CS1 одржавање: Непрепознат језик (веза)

Literatura

Bernstein HB, Compans RW (1992). „Sulfation of the human immunodeficiency virus envelope glycoprotein”. J. Virol. 66 (12): 6953—9. PMC 240329 . PMID 1433500. doi:10.1128/JVI.66.12.6953-6959.1992.
Shilatifard A; Merkle RK; Helland DE; et al. (1993). „Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine”. J. Virol. 67 (2): 943—52. PMC 237448 . PMID 8419650. doi:10.1128/JVI.67.2.943-952.1993.
Hemmerich S; Lee JK; Bhakta S; et al. (2001). „Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family”. Glycobiology. 11 (1): 75—87. PMID 11181564. doi:10.1093/glycob/11.1.75 .
Li X; Tu L; Murphy PG; et al. (2001). „CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin”. J. Leukoc. Biol. 69 (4): 565—74. PMID 11310842. S2CID 8888883. doi:10.1189/jlb.69.4.565 .
Yeh JC; Hiraoka N; Petryniak B; et al. (2001). „Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase”. Cell. 105 (7): 957—69. PMID 11439191. S2CID 18674112. doi:10.1016/S0092-8674(01)00394-4 .
Uchimura K; El-Fasakhany FM; Hori M; et al. (2002). „Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression”. J. Biol. Chem. 277 (6): 3979—84. PMID 11726653. doi:10.1074/jbc.M106587200 .
Seko A, Nagata K, Yonezawa S, Yamashita K (2003). „Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma”. Glycobiology. 12 (6): 379—88. PMID 12107080. doi:10.1093/glycob/12.6.379 .
Akama TO, Misra AK, Hindsgaul O, Fukuda MN (2003). „Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate”. J. Biol. Chem. 277 (45): 42505—13. PMID 12218059. doi:10.1074/jbc.M207412200 .
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
de Graffenried CL, Bertozzi CR (2003). „Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis”. J. Biol. Chem. 278 (41): 40282—95. PMID 12855678. doi:10.1074/jbc.M304928200 .
Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285 .
de Graffenried CL, Bertozzi CR (2004). „The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity”. J. Biol. Chem. 279 (38): 40035—43. PMID 15220337. doi:10.1074/jbc.M405709200 .
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Otsuki T; Ota T; Nishikawa T; et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries”. DNA Res. 12 (2): 117—26. PMID 16303743. doi:10.1093/dnares/12.2.117 .
Timson G; Banavali S; Gutierrez MI; et al. (2006). „High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia”. Cancer Lett. 242 (2): 239—44. PMID 16386360. doi:10.1016/j.canlet.2005.11.012.

Enzimi

Teme

Tipovi

EC1 Oksidoreduktaze /spisak
EC2 Transferaze /spisak
EC3 Hidrolaze /spisak
EC4 Lijaze /spisak
EC5 Izomeraze /spisak
EC6 Ligaze /spisak

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6